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Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 3 / No. 1 / Published : 2003-04

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Original Article :

Pola Hambatan Asam Anakardat Terhadap Aktivitas Thiol Protease

Pola Hambatan Asam Anakardat Terhadap Aktivitas Thiol Protease

Author :

  1. Tutuk Budiati --> Bagian Kimia Farmasi Fakultas Farmasi Universitas Airlangga

Abstract :

Proteolytic activity of papain was assayed using L-BAPA as the substrate. The Km of papain is 0,83 x 10-3 M; it means that the complex of L-BAPA and papain are held together rather weakly. Anacardic acids, isolated from CNSL, will inhibit proteolytic activity of papain competitively. Anacardic acids interact with the active side of papain through some kind of bond other than covalent bond.

Keyword :

proteolytic activity, papain, anacardic acid, competitive inhibitor,


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