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Jurnal Penelitian Medika Eksakta

ISSN : 1411-6626

Vol. 4 / No. 1 / Published : 2003-04

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Original Article :

EFFECT OF POLYPHENOL FRACTION OF Gendarussa vulgaris Nees ON DECREASE HYALURONIDASE ACTIVITY BY IN VITRO FERTILIZATION TEST

PENGARUH FRAKSI POLIFENOL Gendarussa vulgaris Nees PADA PENURUNAN AKTIVITAS HIALURONIDASE SPERMATOZOA MENCIT MELALUI UJI FERTILISASI IN VITRO

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    Abstract :

    Proving ethnomedicinal information of Gendarussa vulgaris Nees. as male contraceptive is one of developing effort of Indonesian traditional drugs. Some researches have been done on various extracts or fraction of G.vulgaris leaf, all to reveal the mechanism of action of active compounds against animal beside elucidating its active compounds.In this research, n-butanol fraction that known to contain flavonoid (polyphenol) by HPLC-DAD was used . Male mice was used as experimental animals, doses with 15 mg/20 g b.w. and 30 mg/20 g b.w. p.o. once a day for 55 days. Decrease of hyaluronidase activity of mice spermatozoa was shown by inhibition of mice spermatozoa penetration in vitro fertilization process after 7 hours incubation.Result shown that administration of the polyphenol fraction, could inhibition mice spermatozoa penetration IVF shown by no zygote developed. Further more also put identified that no dispersion of cumulus oophorus or granulose cell.

    Keyword :

    Gendarussa vulgaris Nees., Hyaluronidase mice spermatozoa, flavonoid, polyphenol, in vitro fertilization,


    Daftar Pustaka :





      Archive Article

      Cover Media Content

      Volume : 4 / No. : 1 / Pub. : 2003-04
      1. The Effect Of Java Ginseng Root Exstrac To Spermatogenesis By Induced Of 2-methoxyethanol
      2. Analysis Of Diffusion Coefficient For Ternary System From Reconstruction Of Off- Axis Hologram With Computer Simulation Program
      3. Efectivity Of Polyclonal Antibody Of Pmsg To Produce Oocyte And Embryo Of Mice
      4. The Prevantion Effect Of The Endothelial Cell By Aqueous Extract Of Garlic (allium Sativum Linn) On Hypercholesterolemia
      5. The Role Of Garlic (allium Sativum) Antioxidant As Hepatoprotector
      6. The Antifertility Activity Of Quercetin Pentaasetat In Male Mice
      7. Effect Of Polyphenol Fraction Of Gendarussa Vulgaris Nees On Decrease Hyaluronidase Activity By In Vitro Fertilization Test
      8. Saliva Buffer Effectivity Difference Between Low Caries And High Caries Patients Before And After Restorations